ADVANCED RESISTIVE EXERCISE VERSUS INTERIM RESISTIVE EXERCISE IMPACT ON BIOMARKERS OF BONE TURNOVER AND SUBSEQUENTLY SPINE HEALTH FOR ASTRONAUTS UNDERGOING PROLONGED SPACE FLIGHT: A SYSTEMATIC REVIEW AND META-ANALYSIS

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dc.contributor.authorBasil Mohammed Ibdah
dc.contributor.authorAbdallah M. A. Sayegh
dc.contributor.authorDana A. F. I. Farghaly
dc.contributor.authorMedha Chakrapani
dc.contributor.authorSara I. T. Abdelnabi
dc.contributor.authorAnahit Galstyan
dc.contributor.authorNatalie Shulaia
dc.date.accessioned2026-09-14T07:25:16Z
dc.date.available2026-09-14T07:25:16Z
dc.date.issued2026-05-12
dc.description.abstractBackground: Spaceflight, once a distant dream for many, is potentially becoming a commodity with recent advancements. Microgravity-related spine abnormalities are expected to increase with the increase of spaceflights conducted by individuals. Objectives: To examine whether Advanced Resistive Exercise (ARED), Interim Resistive Exercise (IRED), or Bisphosphate and ARED (Bis+ARED) best maintained bone turnover biomarkers, minimizing subsequent effects on the spine during extended spaceflight Methods: Following PRISMA guidelines, 86 studies were identified from PubMed, EmBase and SCOPUS. Studies had to be double-arm discussing ARED as the intervention with IRED and/or Bis+ARED as a comparison throughout multiple flight phases for calcifediol, calcitriol, and urinary calcium. Studies had to be in English; no limit on years was set. Meta-analysis of Mean Difference (MD) with 95% CI was conducted using STATA MP (v.17.0). A total of 3 studies encompassing 2 prospective cohorts and 1 clinical trial were examined in the quantitative comparison between ARED and IRED/Bis+Ared. With a total number of 52 participants.
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/10772
dc.language.isoen
dc.publisherDeanship of Scientific Research - Al-Quds University
dc.titleADVANCED RESISTIVE EXERCISE VERSUS INTERIM RESISTIVE EXERCISE IMPACT ON BIOMARKERS OF BONE TURNOVER AND SUBSEQUENTLY SPINE HEALTH FOR ASTRONAUTS UNDERGOING PROLONGED SPACE FLIGHT: A SYSTEMATIC REVIEW AND META-ANALYSIS
dc.typeArticle
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