ADVANCED RESISTIVE EXERCISE VERSUS INTERIM RESISTIVE EXERCISE IMPACT ON BIOMARKERS OF BONE TURNOVER AND SUBSEQUENTLY SPINE HEALTH FOR ASTRONAUTS UNDERGOING PROLONGED SPACE FLIGHT: A SYSTEMATIC REVIEW AND META-ANALYSIS
Date
2026-05-12
Authors
Basil Mohammed Ibdah
Abdallah M. A. Sayegh
Dana A. F. I. Farghaly
Medha Chakrapani
Sara I. T. Abdelnabi
Anahit Galstyan
Natalie Shulaia
Journal Title
Journal ISSN
Volume Title
Publisher
Deanship of Scientific Research - Al-Quds University
Abstract
Background: Spaceflight, once a distant dream for many, is potentially becoming a commodity with recent advancements. Microgravity-related spine abnormalities are expected to increase with the increase of spaceflights conducted by individuals.
Objectives: To examine whether Advanced Resistive Exercise (ARED), Interim Resistive Exercise (IRED), or Bisphosphate and ARED (Bis+ARED) best maintained bone turnover biomarkers, minimizing subsequent effects on the spine during extended spaceflight
Methods: Following PRISMA guidelines, 86 studies were identified from PubMed, EmBase and SCOPUS. Studies had to be double-arm discussing ARED as the intervention with IRED and/or Bis+ARED as a comparison throughout multiple flight phases for calcifediol, calcitriol, and urinary calcium. Studies had to be in English; no limit on years was set. Meta-analysis of Mean Difference (MD) with 95% CI was conducted using STATA MP (v.17.0). A total of 3 studies encompassing 2 prospective cohorts and 1 clinical trial were examined in the quantitative comparison between ARED and IRED/Bis+Ared. With a total number of 52 participants.