Effects of Extremely Low Frequency Magnetic Field on the Secondary Structures of β-Amyloid and Human Serum Albumin

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dc.contributor.authorDarwish, Saqer Mohamad
dc.contributor.authorAlsamamra, Husain Rashad
dc.contributor.authorAbusharkh, Sawsan Eid
dc.contributor.authorKhalid, Imtiaz Mohammed
dc.contributor.authorAlfaqeh, Rania Abdeljalil
dc.contributor.authorAbuteir, Musa Mahmoud
dc.date.accessioned2019-12-09T12:23:53Z
dc.date.available2019-12-09T12:23:53Z
dc.date.issued2018-01-10
dc.description.abstractHuman serum albumin and β-amyloid were exposed to extremely low frequency (ELF) magnetic field of 1.5 mT intensity and 50 Hz frequency. The effects of exposure were investigated in the mid-infrared region by means of Fourier selfdeconvolution spectroscopic analysis. The experimental results suggest that exposure to the ELF magnetic field has reversible effects on the out of phase combination of N–H in plane bending and C–N stretching vibrations of the secondary structures of the two proteins. The exposure of β-amyloid and human serum albumin to ELF magnetic field affected the absorption spectra of the vibration bands by changes in peak positions for the amide II bands and changes of intensities in most of the bands in the amide I and amide II regions. In the fingerprint region, the most sensitive vibrations to the magnetic field are found to be in the (720-600) cm-I range. After removing the magnetic field, it took the vibration bands more than 10 minutes of a gradual change toward returning to their original spectra, obtained before the exposure. It is suggested that hydrogen bonds can alter the frequency of a stretching vibration depending on the increase or decrease of strain on the vibrations.en_US
dc.description.sponsorshipThis work is supported by the German Research Foundation DFG Grant No. DR228/24-2.en_US
dc.identifier.citationSaqer Mohamad Darwish, Husain Rashad Alsamamra, Sawsan Eid Abusharkh, Imtiaz Mohammed Khalid, Rania Abdeljalil Alfaqeh, Musa Mahmoud Abuteir. Effects of Extremely Low Frequency Magnetic Field on the Secondary Structures of β-Amyloid and Human Serum Albumin. European Journal of Biophysics. Vol. 5, No. 6, 2017, pp. 89-103. doi: 10.11648/j.ejb.20170506.11en_US
dc.identifier.issn2329-1737
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/5002
dc.language.isoenen_US
dc.publisherScience publishing groupen_US
dc.subjectFTIR-Spectroscopyen_US
dc.subjectELF-Magnetic Fielden_US
dc.subjectβ-Amyloiden_US
dc.subjectHASen_US
dc.subjectProtein Dynamicsen_US
dc.titleEffects of Extremely Low Frequency Magnetic Field on the Secondary Structures of β-Amyloid and Human Serum Albuminen_US
dc.typeArticleen_US
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