Evolutionary changes in the genome of Mycobacterium tuberculosis and the human genome from 9000 years BP until modern times

dc.contributor.author Spigelman, Mark
dc.contributor.author Donoghue, Helen D.
dc.contributor.author Abdeen, Ziad
dc.contributor.author Ereqat, Suheir
dc.contributor.author Sarie, Issa
dc.contributor.author Greenblatt, Charles L.
dc.contributor.author Pap, Ildiko
dc.contributor.author Szikossy, Ildiko
dc.contributor.author Hershkovitz, Israel
dc.contributor.author Bar-Gal, Gila Kahila
dc.contributor.author Matheson, Carney
dc.date.accessioned 2018-09-02T19:54:22Z
dc.date.available 2018-09-02T19:54:22Z
dc.date.issued 2015-02-13
dc.description.abstract The demonstration of Mycobacterium tuberculosis DNA in ancient skeletons gives researchers an insight into its evolution. Findings of the last two decades sketched the biological relationships between the various species of tubercle bacilli, the time scale involved, their possible origin and dispersal. This paper includes the available evidence and on-going research. In the submerged Eastern Mediterranean Neolithic village of Atlit Yam (9000 BP), a human lineage of M. tuberculosis, defined by the TbD1 deletion in its genome, was demonstrated. An infected infant at the site provides an example of active tuberculosis in a human with a naïve immune system. Over 4000 years later tuberculosis was found in Jericho. Urbanization increases population density encouraging M. tuberculosis/human co-evolution. As susceptible humans die of tuberculosis, survivors develop genetic resistance to disease. Thus in 18th century Hungarian mummies from V ac, 65% were positive for tuberculosis yet a 95-year-old woman had clearly survived a childhood Ghon lesion. Whole genome studies are in progress, to detect changes over the millennia both in bacterial virulence and also host susceptibility/resistance genes that determine the NRAMP protein and Killer Cell Immunoglobulin-like Receptors (KIRs). This paper surveys present evidence and includes initial findings. en_US
dc.description.sponsorship The contribution made by our many collaborators, researchers and students is gratefully acknowledged. Special acknowledgement is due to Dr Angela Gernaey (deceased) who helped pioneer the early mycolic acid work on the bison bone. en_US
dc.identifier.issn 1472-9792
dc.identifier.uri https://dspace.alquds.edu/handle/20.500.12213/796
dc.language.iso en_US en_US
dc.publisher Elsevier en_US
dc.subject Ancient DNA en_US
dc.subject Evolution en_US
dc.subject KIR historical specimens en_US
dc.subject Mycobacterium tuberculosis en_US
dc.subject SLC11A1 gene en_US
dc.subject Solute Carrier family genes en_US
dc.title Evolutionary changes in the genome of Mycobacterium tuberculosis and the human genome from 9000 years BP until modern times en_US
dc.type Article en_US
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