Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential

Date
2019-02-12
Authors
Abu-Lafi, Saleh
Akkawi, Mutaz
Abu-Remeleh, Qassem
Qutob, Mutaz
Lutgen, Pierre
Journal Title
Journal ISSN
Volume Title
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Abstract
Natural curcuminod isolates from turmeric Curcuma longa that belongs to ginger family Zingiberaceae were collected using reversed phase preparative HPLC coupled to photodiode array detector and their in-vitro effect on β-hematin inhibition were explored. Turmeric ethanolic crude extract was ten-fold less active in comparison to chloroquine positive control. Moreover, semi-quantitative and quantitative analysis results revealed that curcumin analytical standard, and to a lesser extent, the turmeric three natural isolates impeded β-hematin formation in a relatively comparable extent to chloroquine and amodiaquine positive controls. This result unequivocally indicates the key role curcumin active ingredient plays as an inhibitor of β-hematin formation. Edible turmeric root powder is commercially available and safe to use.
Description
Keywords
curcumin, prep-HPLC, curcuma longa, antimalaria, β-hematin, chloroquine
Citation
TY - JOUR AU - Abu-Lafi, Saleh AU - Akkawi, Mutaz AU - Abouremeleh, Qassem AU - M., Qutob AU - Lutgen, Pierre PY - 2019/02/12 SP - T1 - Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential VL - 7 DO - 10.15406/ppij.2019.07.00228 JO - Pharmacy & Pharmacology International Journal ER -