Epidemiological and clinical features of cutaneous leishmaniases in Jenin District,Palestine, including characterisation of the causative agents in clinical samples

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dc.contributor.authorAzmi, Kifaya
dc.contributor.authorSchönian, Gabriele
dc.contributor.authorNasereddin, Abedelmajeed
dc.contributor.authorSchnur, Lionel F.
dc.contributor.authorSawalha, Samir
dc.contributor.authorEreqat, Suheir
dc.contributor.authorAmro, Ahmad
dc.contributor.authorQaddomi, Sharif E.
dc.contributor.authorAbdeen, Ziad
dc.date.accessioned2018-09-22T09:01:32Z
dc.date.available2018-09-22T09:01:32Z
dc.date.issued2012-07-24
dc.description.abstractDuring 2002–2009, 466 cases of cutaneous leishmaniasis (CL) were reported from Jenin District, Palestine, affecting both genders. The average annual incidence was 23 cases per 100 000 inhabitants, increasing with age in children. Most cases presented a single lesion, generally on the face. Diagnosis and species identification was done by applying internal transcribed spacer 1 (ITS1) RFLP analysis to 47 isolates, of which 44 (93.6%) were Leishmania tropica and 3 (6.4%) were L. major. RFLP analysis was also performed on 256 skin tissue scrapings spotted onto filter papers, showing that 138 (53.9%) were positive, of which 50.7% were infected with L. tropica, 17.4% with L. major and 2.9% with L. donovani s.l., and 29.0% could not be identified. This is the first report from Palestine on human CL caused by L. infantum. Nine of the strains of L. tropica were subjected to multilocus enzyme electrophoresis, six of which belonged to the zymodeme MON-137 and three to a new zymodeme (MON-307). This separation was corroborated by excreted factor serotyping. This observation modifies the classical epidemiological view of CL in Palestine. Jenin District is an active focus of CL caused by L. tropica, where Phlebotomus sergenti, the putative vector, is abundant. These data suggest that CL is a zoonotic infection, but an animal reservoir has not been found.en_US
dc.description.sponsorshipThis research was supported by the Deutsche Forschungsgemeinschaft (DFG) as part of a German–Israeli–Palestinian co-operation project on the Emergence of Cutaneous Leishmaniasis in the Middle East: an investigation of Leishmania tropica in the Palestinian Authority and Israel.en_US
dc.identifier.issn0035-9203
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/964
dc.language.isoen_USen_US
dc.publisherElsevieren_US
dc.subjectCutaneous leishmaniasisen_US
dc.subjectLeishmania tropicaen_US
dc.subjectEpidemiologyen_US
dc.subjectPolymerase chain reactionen_US
dc.subjectZymodemeen_US
dc.subjectPalestineen_US
dc.titleEpidemiological and clinical features of cutaneous leishmaniases in Jenin District,Palestine, including characterisation of the causative agents in clinical samplesen_US
dc.typeArticleen_US
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