Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review

Date
2018-05-28
Authors
Zeiadeh, Isra’
Najjar, Anas
Karaman, Rafik
Journal Title
Journal ISSN
Volume Title
Publisher
MDPI AG
Abstract
The blood brain barrier (BBB) is a dynamic and functional structure which poses a vast challenge in the development of drugs acting on the central nervous system (CNS). While most substances are denied BBB crossing, selective penetration of substances mainly occurs through diffusion, carrier mediated transport, or receptor mediated transcytosis. Methods: Strategies in enhancing BBB penetration have been reviewed and summarized in accordance with their type of formulation. Highlights in monoclonal antibodies, peptide-vectors, nanoparticles, and simple prodrugs were included. Conclusion: Nanoparticles and simple prodrugs, for example, can be used for efficient BBB penetration through inhibition of efflux mechanisms, however, monoclonal antibodies are the most promising strategy in BBB penetration. Close follow-up of future development in this area should confirm our expectation.
Description
Keywords
blood brain barrier, drug penetration strategies, monoclonal antibody, peptide-vector, nanoparticles, prodrugs
Citation
@inproceedings{Zeiadeh2018StrategiesFE, title={Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review}, author={Isra' Zeiadeh and Anas Najjar and Rafik Karaman}, booktitle={Molecules}, year={2018} }