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dc.contributor.authorKaraman, Rafik
dc.contributor.authorAl-Kurd, Samia
dc.contributor.authorYaghmour, Reem
dc.contributor.authorAmro, Ahmad
dc.contributor.authorKaraman, Donia
dc.date.accessioned2018-09-08T07:06:07Z
dc.date.available2018-09-08T07:06:07Z
dc.date.issued2015-09-10
dc.identifier.issn2277– 7105
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/855
dc.description.abstractTwo novel prodrugs of amoxicillin and cephalexin (amoxicillin ProD 1 and cephalexin ProD 1, respectively) were designed and synthesized to improve the stability and bitter sensation of their parent drugs. The in vitro susceptibility for both prodrugs was determined against Escherichia coli, staphylococcus epidermidis, staphylococcus aureus, Klebsiella pneumonia, streptococcus group A and streptococcus group B, and was compared to that of their active parent drugs.The antibacterial screening demonstrates that amoxicillin ProD 1 and cephalexin ProD 1 were found to be active and are considered among a small number of prodrugs that have therapeutic activity themselves before undergoing interconversion via enzymatic or chemical reaction to their corresponding active parent drugs. Both prodrugs exhibit their antibacterial activity against different types of bacterial strains due to the presence of β- lactam ring in their structures. In addition, it is expected that these novel prodrugs will be much more stable in aqueous media than their corresponding active parent drugs due to the fact that the chemically sensitive amine group contained in the active parent drug structures is replaced with an amide, more chemically stable group, in the corresponding prodrugs.en_US
dc.language.isoen_USen_US
dc.subjectAntibacterialsen_US
dc.subjectamoxicillinen_US
dc.subjectcephalexinen_US
dc.subjectprodrugsen_US
dc.subjectbitter sensationen_US
dc.subjectcleavageen_US
dc.titleAntibacterial Activity of Novel Prodrugs of Amoxicillin and Cephalexinen_US
dc.typeArticleen_US


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