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dc.contributor.authorElqadi, Muawiyah
dc.contributor.authorEweidat, Khaled
dc.contributor.authorAbu Sabha, Mosa
dc.contributor.authorYagmour, Asil
dc.contributor.authorSabarneh, Anas
dc.contributor.authorNasereddin, Abedalmajeed
dc.contributor.authorEreqat, Suheir
dc.date.accessioned2021-09-20T20:08:50Z
dc.date.available2021-09-20T20:08:50Z
dc.date.issued2021-08-30
dc.identifier.citationarticle: Elqadi M, Eweidat K, Abu Sabha M, et al. Methylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patients. J Clin Lab Anal. 2021;00:e23994. https://doi.org/10.1002/jcla.23994en_US
dc.identifier.issn1098-2825
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/6454
dc.description.abstractBackground: Dyslipidemia in diabetes is common and characterized by hypertriglyc- eridemia with decreased levels of high-density lipoprotein. The objective of this study was to assess the prevalence of MTHFR C677T polymorphism in Palestinian T2DM patients and to investigate the association between this polymorphism and lipid pro- file in diabetic patients with and without dyslipidemia. Methods: A total of 208 T2DM patients including 98 with dyslipidemia and 110 with- out dyslipidemia were enrolled in this study. The MTHFR C677T genotyping was con- ducted by PCR-RFLP followed by agarose gel electrophoresis. Results: There were no significant differences in either the genotype distribution or allele frequency in T2DM patients with or without dyslipidemia (37.8% CC, 54% CT, 8.2% TT vs. 48.2% CC, 41.8% CT, 11% TT; p = 0.209). However, among the dys- lipidemic group, the TT carriers have a higher HDL level (46.8 ± 17.8) compared to (CC+CT) carriers (34.68 + 11.9) (p = 0.01). In the group without dyslipidemia, there was a significant elevation in diastolic blood pressure (DBP) among the CC carri- ers (83.6 ± 10.6) compared to those who carried at least one mutant allele (CT+TT) (78.1 ± 11.1) (p = 0.009). Conclusions: The study shows that in our Palestinian population the MTHFR 677TT genotype lowers DBP significantly in patients without dyslipidemia and is related to increased level of HDL in diabetic dyslipidemia patients.en_US
dc.description.sponsorshipAuthors would like to thank all the study participants.en_US
dc.language.isoenen_US
dc.publisherJohn Wiley & Sons, Inc.en_US
dc.subjectC677T SNPen_US
dc.subjectdyslipidemiaen_US
dc.subjectlipid profileen_US
dc.subjectMTHFRen_US
dc.subjectT2DMen_US
dc.titleMethylenetetrahydrofolate reductase C677T gene polymorphism and the association with dyslipidemia in type 2 diabetic Palestinian patientsen_US
dc.typeArticleen_US


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