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dc.contributor.authorAbu-Lafi, Saleh
dc.contributor.authorAkkawi, Mutaz
dc.contributor.authorAbu-Remeleh, Qassem
dc.contributor.authorQutob, Mutaz
dc.contributor.authorLutgen, Pierre
dc.date.accessioned2019-11-30T12:03:50Z
dc.date.available2019-11-30T12:03:50Z
dc.date.issued2019-02-12
dc.identifier.citationTY - JOUR AU - Abu-Lafi, Saleh AU - Akkawi, Mutaz AU - Abouremeleh, Qassem AU - M., Qutob AU - Lutgen, Pierre PY - 2019/02/12 SP - T1 - Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential VL - 7 DO - 10.15406/ppij.2019.07.00228 JO - Pharmacy & Pharmacology International Journal ER -en_US
dc.identifier.issn2373-6367
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/4975
dc.description.abstractNatural curcuminod isolates from turmeric Curcuma longa that belongs to ginger family Zingiberaceae were collected using reversed phase preparative HPLC coupled to photodiode array detector and their in-vitro effect on β-hematin inhibition were explored. Turmeric ethanolic crude extract was ten-fold less active in comparison to chloroquine positive control. Moreover, semi-quantitative and quantitative analysis results revealed that curcumin analytical standard, and to a lesser extent, the turmeric three natural isolates impeded β-hematin formation in a relatively comparable extent to chloroquine and amodiaquine positive controls. This result unequivocally indicates the key role curcumin active ingredient plays as an inhibitor of β-hematin formation. Edible turmeric root powder is commercially available and safe to use.en_US
dc.description.sponsorshipWe are grateful for Prof. Mohammad Abul Haj for his helpful discussions and insightful comments.en_US
dc.language.isoenen_US
dc.subjectcurcuminen_US
dc.subjectprep-HPLCen_US
dc.subjectcurcuma longaen_US
dc.subjectantimalariaen_US
dc.subjectβ-hematinen_US
dc.subjectchloroquineen_US
dc.titleCurcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potentialen_US
dc.typeArticleen_US


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