Show simple item record

dc.contributor.authorZeiadeh, Isra’
dc.contributor.authorNajjar, Anas
dc.contributor.authorKaraman, Rafik
dc.date.accessioned2019-11-06T11:37:46Z
dc.date.available2019-11-06T11:37:46Z
dc.date.issued2018-05-28
dc.identifier.citation@inproceedings{Zeiadeh2018StrategiesFE, title={Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review}, author={Isra' Zeiadeh and Anas Najjar and Rafik Karaman}, booktitle={Molecules}, year={2018} }en_US
dc.identifier.issn1420-3049
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/4868
dc.description.abstractThe blood brain barrier (BBB) is a dynamic and functional structure which poses a vast challenge in the development of drugs acting on the central nervous system (CNS). While most substances are denied BBB crossing, selective penetration of substances mainly occurs through diffusion, carrier mediated transport, or receptor mediated transcytosis. Methods: Strategies in enhancing BBB penetration have been reviewed and summarized in accordance with their type of formulation. Highlights in monoclonal antibodies, peptide-vectors, nanoparticles, and simple prodrugs were included. Conclusion: Nanoparticles and simple prodrugs, for example, can be used for efficient BBB penetration through inhibition of efflux mechanisms, however, monoclonal antibodies are the most promising strategy in BBB penetration. Close follow-up of future development in this area should confirm our expectation.en_US
dc.language.isoenen_US
dc.publisherMDPI AGen_US
dc.subjectblood brain barrieren_US
dc.subjectdrug penetration strategiesen_US
dc.subjectmonoclonal antibodyen_US
dc.subjectpeptide-vectoren_US
dc.subjectnanoparticlesen_US
dc.subjectprodrugsen_US
dc.titleStrategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Reviewen_US
dc.typeArticleen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record