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dc.contributor.authorAttieh, Hanadi A.
dc.contributor.authorAbu Lafi, Saleh
dc.contributor.authorJaber, Suhair
dc.contributor.authorAbu-Remeleh, Qassem
dc.contributor.authorLutgen, Pierre
dc.contributor.authorAkkawi, Mutaz
dc.date.accessioned2018-09-29T13:32:57Z
dc.date.available2018-09-29T13:32:57Z
dc.date.issued2015-10-10
dc.identifier.issn1996-0875
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/1023
dc.description.abstractMalaria remains one of the prominent public health problems that lead to severe morbidity and mortality in many developing countries around the globe. New antimalarial drugs are urgently needed due to the emergence of antimalarial-resistant strains of Plasmodium falciparum. In previous studies, we tested several plants extracts that are capable of inhibiting β-hematin formation, with efficiency similar to chloroquine. In the current study, the effect of cinnamon ethanol and water extracts on inhibiting β- hematin formation was studied. Powdered cinnamon extracts and bark in a stick form were investigated using various extraction methods. A semi-quantitative in vitro method, based on the inhibition of ferriprotoporphyrin IX (FP) bio-crystallization developed by Deharo et al. (2002) was utilized. Water extracts of cinnamon revealed potential activity even at low concentration of infusions, which was manifested by a high capability to inhibit β-hematin formation in vitro.en_US
dc.language.isoen_USen_US
dc.publisherAcademic Journalsen_US
dc.subjectCinnamonen_US
dc.subjectferriprotoporphyrin (IX)en_US
dc.subjectβ-hematinen_US
dc.subjectchloroquineen_US
dc.subjecthemozoinen_US
dc.subjectmalariaen_US
dc.titleCinnamon bark water-infusion as an in-vitro inhibitor of β-hematin formationen_US
dc.typeArticleen_US


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