Neuroscience

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Alpha and Theta Band Power Alterations on EEG are Linked to Psychological, but not Somatic, Symptom Severity in Patients with Major Depressive Disorder
(Al-Quds University, Deanship of Scientific Research, 2022-05-11) Nawras A. Sawafta; Abdul-Rahman S. Sawalma; Mohammad M. Herzallah
Background: Major depressive disorder (MDD) is a serious psychiatric disorder characterized by low mood, loss of pleasure, and other psychological and somatic symptoms. Previous studies show that MDD is associated with changes in alpha and theta oscillations measured by electroencephalography (EEG). Yet, most studies did not differentiate between subsets of MDD symptoms and their relationship to different brain oscillations.
Reinforcement Learning Predicts Response to SSRIs in Medication-Naïve Patients with Major Depressive Disorder
(Al-Quds University, Deanship of Scientific Research, 2022-05-11) Yasmeen Sultan; Mahmud A. Sehwail; Mohammad M. Herzallah
Background: Patients with major depressive disorder (MDD) exhibit hyposensitivity to positive reinforcement and hypersensitivity to negative reinforcement. In patients who respond to treatment, selective serotonin reuptake inhibitor (SSRI) antidepressants arguably modulate MDD symptoms by attenuating learning from negative reinforcement. However, only 30% of patients with MDD respond to antidepressants including SSRI. Cognitive differences between responders and non-responders were heretofore not investigated medication-naïve patients with MDD.