Upregulation of MIR4500HG003 LncRNA Expression in Response to Hypoxia, HGF, and Serum Starvation in the Triple-Negative Breast Cancer Cell Line MDA-MB-231
Date
2025-06-01
Authors
Sadeen Jawabreh
Journal Title
Journal ISSN
Volume Title
Publisher
Deanship of Research - Al-Quds University
Abstract
Background: Cancer remains a leading cause of global mortality, with triple-negative breast cancer (TNBC) representing one of its most aggressive and difficult-to-treat subtypes. TNBC lacks expression of estrogen receptors (ER), progesterone receptors (PR), and HER2, eliminating the possibility of targeted hormonal therapies. As a result, it is associated with a high rate of early metastasis and poor clinical outcomes. Emerging research has identified long non-coding RNAs (lncRNAs) as key regulators of tumor progression, metastasis, and therapy resistance. One such lncRNA, MIR4500HG003, was recently reported to promote TNBC metastasis via the miR-483-3p/MMP9 axis, yet this is the only study that has investigated it to date. Beyond this single publication, nothing is known about how MIR4500HG003 is regulated in response to tumor microenvironmental stressors, which are critical for metastatic adaptation.