Pharmaceutical Sciences العلوم الصيدلانية

Permanent URI for this collection

https://dspace.alquds.edu/handle/20.500.12213/1086

Browse

Browsing Pharmaceutical Sciences العلوم الصيدلانية by Author "Bashaer Zaher Mustafa Abd Nabi"

Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    Formulation and Assessment of Tooth Spray
    (Al-Quds University, 2025-04-26) Bashaer Zaher Mustafa Abd Nabi; بشائر زاهر مصطفى عبد النبي
    Nowadays, essential oils are commonly utilized to treat and prevent a number of conditions linked to dental illness, such as tooth decay, gingivitis, and halitosis. The purpose of this study was to develop and assess a tooth spray in a novel formulation and dosage form, as well as to examine the antibacterial qualities of essential oils and herbal tooth sprays against microorganisms that cause dental disease. Three essential oils clove, peppermint, and sage were used as active components in equal amounts to create a dental spray formulation for this investigation. In order to guarantee stability and usefulness, the formulation also contained the proper excipients. To determine the product's quality and efficacy, a number of tests were carried out, including stability, chemical, physical, and antibacterial ones. The outcomes confirmed the dental spray's acceptability as a natural oral care product by showing that it is stable, homogenous, effective, and safe to use at room temperature. Because of its stability, ease of use, and ability to transport active chemicals straight to the mouth cavity, a dental spray was selected as the dosage form. Compared to alternative dose forms like rinses or gels, sprays offer a quicker start of action, consistent dispersion throughout the targeted region, and better patient compliance. Additionally, this approach minimizes systemic exposure and any adverse effects by enabling targeted therapy. Tooth spray was formulated as a new dosage form not available in the market. The studies suggested acceptability criteria, which include being consistent, flexible, non-sticky, and devoid of odors and stains, can be met by tooth sprays. The sprayed component exhibits antibacterial and antifungal properties, according to incubation-based microbiological investigations. When the pH of the mouth starts to fall below 5.5, tooth decay may result. In tooth spray, bases are used to counteract oral acid. The tooth spray was therefore created with a pH of 8.5. The stability study results confirmed the spray's effectiveness based on the comparison between zero-time data and the results obtained after two months.