Now showing items 1-6 of 6
Design, synthesis and in vitro kinetic study of tranexamic acid prodrugs for the treatment of bleeding conditions
(Springer Science+Business Media Dordrecht, 2013-07-13)
Based on density functional theory (DFT) calculations for the acid-catalyzed hydrolysis of several maleamic acid amide derivatives four tranexamic acid prodrugs were designed. The DFT results on the acid catalyzed hydrolysis ...
Diclofenac Codrugs and Prodrugs-Three Decades of Design
(WJPPS,Dr. T Pal, 2015-06-08)
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release the active parent drug. The prodrug’s cleavage can be catalyzed by metabolic enzymes or can occur by chemical means without ...
Design, Synthesis, Characterization and In-Vitro Kinetic Study of Novel Antibacterials Prodrugs
(WJPR,Tara Pal,WJPR, 2015-10-30)
A number of marketed antibacterial drugs suffer several problems, such as bitter sensation and low stability which lead to patient incompliance. The prodrug approach is considered the most promising and extremely exciting ...
Prodrugs targeting the central nervous system (cns)
The classical approach for delivery of drugs into the central nervous system (CNS) is associated with adverse effects and it has many limitations. Therefore, extensive efforts have been done in searching and developing ...
Overview on the Recent Drugs Delivery Approaches
(Aperito Online Publishing, 2016-02-01)
This review provides the reader a concise overview of the different biological barriers that hinder the delivery of therapeutic agents through membranes, such as intestinal mucosa, Brain Blood Barrier (BBB), and mediators ...
Antibacterial Predrugs-from 1899 till 2015
(WJPPS,Dr. T Pal, 2015-07-08)
The predrug (prodrug) term involves chemically modified inert compound which upon an administration releases the active parent drug to elicit its pharmacological response within the body. For many years, the predrug ...