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Antibacterial Activity of Novel Prodrugs of Amoxicillin and Cephalexin
Two novel prodrugs of amoxicillin and cephalexin (amoxicillin ProD 1 and cephalexin ProD 1, respectively) were designed and synthesized to improve the stability and bitter sensation of their parent drugs. The in vitro ...
Anti-cancer Prodrugs-Three Decades of Design
The conventional old treatment method for cancer therapy is associated with severe side effects along with several limitations. Therefore, searching and developing new methods for cancer became crucial. This mini review ...
Strategies for Enhancing the Permeation of CNS-Active Drugs through the Blood-Brain Barrier: A Review
(MDPI AG, 2018-05-28)
The blood brain barrier (BBB) is a dynamic and functional structure which poses a vast challenge in the development of drugs acting on the central nervous system (CNS). While most substances are denied BBB crossing, ...
Design, Synthesis and In-vitro Kinetic Study of Atovaquone Prodrug for the Treatment of Malaria
(WJPR,Tara Pal,WJPR, 2015-09-23)
Using DFT molecular orbital at B3LYP 6-31G (d,p) and B3LYP/311+G (d,p) levels and molecular mechanics (MM2) calculations of the hydrolysis of Bruice’s di-carboxylic semi-esters 1–5 several atovaquone prodrugs were ...
The prodrug approach in the era of drug design
(Taylor & Francis, 2018-12-18)
Prodrugs are inactive precursors of an active drug designed to be bioconverted (activated) post administration with the main aim of improving the pharmacokinetic properties of the parent drug. Prodrugs have been successful ...
Antibacterial Prodrugs to Overcome Bacterial Resistance
Bacterial resistance to present antibiotics is emerging at a high pace that makes the development of new treatments a must. At the same time, the development of novel antibiotics for resistant bacteria is a slow-paced ...