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Design, Synthesis and In-vitro Kinetic Study of Atovaquone Prodrug for the Treatment of Malaria 

Karaman, Rafik; Fattash, Beesan; Karaman, Donia (‎WJPR,Tara Pal,WJPR, 2015-09-23)
Using DFT molecular orbital at B3LYP 6-31G (d,p) and B3LYP/311+G (d,p) levels and molecular mechanics (MM2) calculations of the hydrolysis of Bruice’s di-carboxylic semi-esters 1–5 several atovaquone prodrugs were ...
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Design, Synthesis, Characterization and In-Vitro Kinetic Study of Novel Antibacterials Prodrugs 

Karaman, Rafik; Dokmak, Ghadeer; Hamarsheh, Omar; Karaman, Donia (‎WJPR,Tara Pal,WJPR, 2015-10-30)
A number of marketed antibacterial drugs suffer several problems, such as bitter sensation and low stability which lead to patient incompliance. The prodrug approach is considered the most promising and extremely exciting ...
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Computer-assisted design for atenolol prodrugs for the use in aqueous formulations 

Karaman, Rafik; Dajani, Khuloud; Hallak, Hussein (Springer-Verlag, 2011-07-23)
Based on stability studies on the drugs atenolol and propranolol and some of their derivatives it is believed that increasing the lipophilicity of the drug will lead to an increase in the stability of its aqueous solutions ...
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Anti-cancer Prodrugs-Three Decades of Design 

Horani, Waad; Thawabteh, Ameen; Scrano, Laura; A. Bufo, Sabino; Mecca, Gennaro; Karaman, Rafik (2015-07-31)
The conventional old treatment method for cancer therapy is associated with severe side effects along with several limitations. Therefore, searching and developing new methods for cancer became crucial. This mini review ...
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Diclofenac Codrugs and Prodrugs-Three Decades of Design 

Dweib, khuloud; Jumaa, Salma; Thawabteh, Ameen; Scrano, Laura; Bufo, Sabino A.; Mecca, Gennaro; Karaman, Rafik (‎WJPPS,Dr. T Pal, 2015-06-08)
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release the active parent drug. The prodrug’s cleavage can be catalyzed by metabolic enzymes or can occur by chemical means without ...
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Antibacterial Predrugs-from 1899 till 2015 

Elayyan, Sabrin; Karaman, Donia; Mecca, Gennaro; Scrano, Laura; Bufo, Sabino A.; Karaman, Rafik (WJPPS,Dr. T Pal, 2015-07-08)
The predrug (prodrug) term involves chemically modified inert compound which upon an administration releases the active parent drug to elicit its pharmacological response within the body. For many years, the predrug ...
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Intramolecular Processes and Their Applications in Prodrugs Approaches- Experimental and Computational Studies 

Karaman, Rafik; Jumaa, Salma; Awwadallah, Heba; Salah, Samya; Khawaja, Yahya; Karaman, Donia (Bentham Science, 2015-11-15)
This review supplies the reader with a detailed overview on the utilization of intramolecular processes for a design and synthesis of prodrugs. It is well known that a respected number of drugs suffer from low ...
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Removal of Antibacterial Agents by Advanced Membrane Technology and ODTMAMicelle-Clay Comlex. 

Awwad, Mohammad; Al-Rimawi, Fuad; Khamis, Mustafa; Khalaf, Samer; Thawabteh, Amin; Karaman, Rafik (2015-06-03)
The efficiency of sequential advanced membrane technology wastewater treatment plant towards removal of amoxicillin and cefuroxime axetil from wastewater was investigated. The sequential system included activated sludge, ...
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Removal of chlorpyrifos using micelle–clay complex and advanced treatment technology 

Qurie, Mohannad; Khamis, Mustafa; Ayyad, Ibrahim; Karaman, Rafik (Balaban Desalination Publications, 2015-10-06)
In this study, the stability of chlorpyrifos, a known pesticide, in fresh water and sludge was investigated. The results showed that chlorpyrifos underwent hydrolysis in both media to give two main metabolites: ...
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Removal of Diclofenac Potassium from Wastewater Using Clay-Micelle Complex 

Karaman, Rafik; Khamis, Mustafa; Quried, Mohannad; Halabieh, Rawan; Makharzeh, Iman; Manassra, Adnan; Abbadi, Jehad; Qtait, Alaa; Nasser, Ahmed (Taylor & Francis, 2012-01-13)
The presence of an ionized carboxyl group in the widely used non-steroidal anti-inflammatory (NSAID) drug diclofenac potassium results in a high mobility of diclofenac and in its low sorption under conditions of slow sand ...
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Karaman, Rafik (57)
Khamis, Mustafa (22)Qurie, Mohannad (11)Scrano, Laura (10)Bufo, Sabino A. (8)Karaman, Donia (8)Khalaf, Samer (6)Abbadi, Jehad (5)Hallak, Hussein (5)Manassra, Adnan (5)... View MoreSubjectProdrugs (6)prodrugs (6)wastewater treatment (6)prodrug (5)Wastewater (5)activated carbon (3)Adsorption (3)amoxicillin (3)DFT calculations (3)resistance (3)... View MoreDate Issued2010 - 2020 (56)2009 - 2009 (1)Has File(s)Yes (57)

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