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Design, Synthesis and In-vitro Kinetic Study of Atovaquone Prodrug for the Treatment of Malaria
(WJPR,Tara Pal,WJPR, 2015-09-23)
Using DFT molecular orbital at B3LYP 6-31G (d,p) and
B3LYP/311+G (d,p) levels and molecular mechanics (MM2)
calculations of the hydrolysis of Bruice’s di-carboxylic semi-esters 1–5
several atovaquone prodrugs were ...
Design, Synthesis, Characterization and In-Vitro Kinetic Study of Novel Antibacterials Prodrugs
(WJPR,Tara Pal,WJPR, 2015-10-30)
A number of marketed antibacterial drugs suffer several problems,
such as bitter sensation and low stability which lead to patient
incompliance. The prodrug approach is considered the most promising
and extremely exciting ...
Computer-assisted design for atenolol prodrugs for the use in aqueous formulations
(Springer-Verlag, 2011-07-23)
Based on stability studies on the drugs atenolol
and propranolol and some of their derivatives it is believed
that increasing the lipophilicity of the drug will lead to an
increase in the stability of its aqueous solutions ...
Anti-cancer Prodrugs-Three Decades of Design
(2015-07-31)
The conventional old treatment method for cancer therapy is associated with severe side effects along with several limitations. Therefore, searching and developing new methods for cancer became crucial. This mini review ...
Diclofenac Codrugs and Prodrugs-Three Decades of Design
(WJPPS,Dr. T Pal, 2015-06-08)
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release the active parent drug. The prodrug’s cleavage can be catalyzed by metabolic enzymes or can occur by chemical means without ...
Antibacterial Predrugs-from 1899 till 2015
(WJPPS,Dr. T Pal, 2015-07-08)
The predrug (prodrug) term involves chemically modified inert
compound which upon an administration releases the active parent
drug to elicit its pharmacological response within the body. For many
years, the predrug ...
Intramolecular Processes and Their Applications in Prodrugs Approaches- Experimental and Computational Studies
(Bentham Science, 2015-11-15)
This review supplies the reader with a detailed overview on the utilization of intramolecular processes
for a design and synthesis of prodrugs. It is well known that a respected number of drugs suffer from low ...
Removal of Antibacterial Agents by Advanced Membrane Technology and ODTMAMicelle-Clay Comlex.
(2015-06-03)
The efficiency of sequential advanced membrane technology wastewater treatment plant towards removal of amoxicillin and
cefuroxime axetil from wastewater was investigated. The sequential system included activated sludge, ...
Removal of chlorpyrifos using micelle–clay complex and advanced treatment technology
(Balaban Desalination Publications, 2015-10-06)
In this study, the stability of chlorpyrifos, a known pesticide, in fresh water and sludge was investigated. The results showed that chlorpyrifos underwent hydrolysis in both media to give two main metabolites: ...
Removal of Diclofenac Potassium from Wastewater Using Clay-Micelle Complex
(Taylor & Francis, 2012-01-13)
The presence of an ionized carboxyl group in the widely used non-steroidal anti-inflammatory (NSAID) drug diclofenac
potassium results in a high mobility of diclofenac and in its low sorption under conditions of slow sand ...