Background The number of cystic fibrosis patients is increasing around the world, Latest forecasts published in the European Respiratory Journal indicate an increase of approximately 50% by 2025 (20% in the child ...

Pyrazine derivatives possess numerous pharmacological effects including but not limited to antiviral, antibiotic, antifungal, diuretic, anticonvulsant, antidiabetic, analgesic and anti proliferative effect. Consequently, ...

Parkinson patients have insufficient dopamine in specific regions of the brain, so attempts have been made to replenish the deficiency in the dopamine. Dopamine itself doesn't cross blood brain barrier, but its precursor, ...

Background and objectives: Unraveling the mechanisms of a number of enzyme models has allowed for the design of efficient chemical devices having the potential to be utilized as prodrug linkers that can be covalently ...

Quantitative structure-activity relationship study was performed to understand the activity of a set of 136 ligands of Translocator protein (TSPO) compounds. QSAR models were developed using multiple linear regression ...