An Aminopyrrolidinyl Phosphonates—A New Class of Antibiotics: Facile Synthesis and Predicted Biological Activity

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dc.contributor.authorAl Quntar, Abed Al Aziz
dc.contributor.authorDweik, Hasan
dc.contributor.authorJabareen, Ahmad
dc.contributor.authorGloriozova, Tatyana A.
dc.contributor.authorDembitsky, Valery M.
dc.date.accessioned2021-01-02T20:21:40Z
dc.date.available2021-01-02T20:21:40Z
dc.date.issued2020-12-04
dc.description.abstractA novel class of aminopyrrolidinyl phosphonates was synthesized in 74% - 80% isolated yield by the addition of three-fold excess of primary amines to diethyl 4-chloro-1-butynylphosphonates. The reaction was carried out at room temperature and in the absence of solvent or catalyst to give solely compounds which showed predicted biological activity based on PASS program. Some of the synthesized derivatives of antibiotics exhibit properties for the treatment of stroke, the treatment of acute neurological disorders, and can also be acetyl esterase inhibitors.en_US
dc.identifier.issn2161-4695
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/6319
dc.language.isoenen_US
dc.publisherScientific Research Publishingen_US
dc.subjectAlkynylphosphonatesen_US
dc.subjectCyclizationen_US
dc.subjectPyrrolidineen_US
dc.subjectβ-Aminophosphonatesen_US
dc.subjectAmine Additionen_US
dc.subjectAntibioticsen_US
dc.titleAn Aminopyrrolidinyl Phosphonates—A New Class of Antibiotics: Facile Synthesis and Predicted Biological Activityen_US
dc.typeArticleen_US
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