Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential
| dc.contributor.author | Abu-Lafi, Saleh | |
| dc.contributor.author | Akkawi, Mutaz | |
| dc.contributor.author | Abu-Remeleh, Qassem | |
| dc.contributor.author | Qutob, Mutaz | |
| dc.contributor.author | Lutgen, Pierre | |
| dc.date.accessioned | 2019-11-30T12:03:50Z | |
| dc.date.available | 2019-11-30T12:03:50Z | |
| dc.date.issued | 2019-02-12 | |
| dc.description.abstract | Natural curcuminod isolates from turmeric Curcuma longa that belongs to ginger family Zingiberaceae were collected using reversed phase preparative HPLC coupled to photodiode array detector and their in-vitro effect on β-hematin inhibition were explored. Turmeric ethanolic crude extract was ten-fold less active in comparison to chloroquine positive control. Moreover, semi-quantitative and quantitative analysis results revealed that curcumin analytical standard, and to a lesser extent, the turmeric three natural isolates impeded β-hematin formation in a relatively comparable extent to chloroquine and amodiaquine positive controls. This result unequivocally indicates the key role curcumin active ingredient plays as an inhibitor of β-hematin formation. Edible turmeric root powder is commercially available and safe to use. | en_US |
| dc.description.sponsorship | We are grateful for Prof. Mohammad Abul Haj for his helpful discussions and insightful comments. | en_US |
| dc.identifier.citation | TY - JOUR AU - Abu-Lafi, Saleh AU - Akkawi, Mutaz AU - Abouremeleh, Qassem AU - M., Qutob AU - Lutgen, Pierre PY - 2019/02/12 SP - T1 - Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential VL - 7 DO - 10.15406/ppij.2019.07.00228 JO - Pharmacy & Pharmacology International Journal ER - | en_US |
| dc.identifier.issn | 2373-6367 | |
| dc.identifier.uri | https://dspace.alquds.edu/handle/20.500.12213/4975 | |
| dc.language.iso | en | en_US |
| dc.subject | curcumin | en_US |
| dc.subject | prep-HPLC | en_US |
| dc.subject | curcuma longa | en_US |
| dc.subject | antimalaria | en_US |
| dc.subject | β-hematin | en_US |
| dc.subject | chloroquine | en_US |
| dc.title | Curcumin, a natural isolate from Curcuma longa (turmeric) with high β-hematin inhibitory potential | en_US |
| dc.type | Article | en_US |