Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women

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dc.contributor.authorEreqat, Suheir
dc.contributor.authorCauchi, Stéphane
dc.contributor.authorEweidat, Khaled
dc.contributor.authorElqadi, Muawiyah
dc.contributor.authorNasereddin, Abedelmajeed
dc.date.accessioned2019-11-17T18:00:16Z
dc.date.available2019-11-17T18:00:16Z
dc.date.issued2019-06-28
dc.description.abstractBackground: Type 2 diabetes mellitus (T2DM) is a multifactorial disease where both genetic and environmental factors contribute to its pathogenesis. The PvuII and XbaI polymorphisms of the estrogen receptor 1 (ESR1) gene have been variably associated with T2DM in several populations. This association has not been studied in the Palestinian population. Therefore, the aim of this study was to investigate the association between the PvuII and XbaI variants in the ESR1 and T2DM and its related metabolic traits among Palestinian women. Methods: This case–control study included 102 T2DM and 112 controls in which PvuII and XbaI variants of the ESR1 gene were genotyped using amplicon based next generation sequencing (NGS). Results: Allele frequencies of both PvuII and XbaI variants were not significantly different between patients and control subjects (P > 0.05). In logestic regression analysis adjusted for age and BMI, the ESR1 PvuII variant was associated with risk of T2DM in three genotypic models (P < 0.025) but the strongest association was observed under over-dominant model (TT+CC vs. TC) (OR = 2.32, CI [1.18–4.55] adjusted P = 0.013). A similar but non-significant trend was also observed for the ESR1 XbaI variant under the over-dominant model (AA+GG vs. AG) (OR = 2.03, CI [1.05–3.95]; adjusted P = 0.035). The frequencies of the four haplotypes (TA, CG, CA, TG) were not significantly different in the T2DM patients compared with control group (P > 0.025). Among diabetic group, an inverse trend with risk of cardio vascular diseases was shown in carriers of CG haplotype compared to those with TA haplotype (OR = 0.28, CI [0.09–0.90]; adjusted P = 0.035). Further, stratified analyses based on ESR1 PvuII and XbaI genotypes revealed no evidence for association with lipid levels (TC, TG, HDL, LDL). Conclusions: This is the first Palestinian study to conclude that ESR1 PuvII and XbaI variants may contribute to diabetes susceptibility in Palestinian women. Identification of genetic risk markers can be used in defining high risk subjects and in prevention trials.en_US
dc.identifier.citationTY - JOUR AU - Ereqat, Suheir AU - Cauchi, Stéphane AU - Eweidat, Khaled AU - Elqadi, Muawiyah AU - Nasereddin, Abedelmajeed PY - 2019/06/28 SP - e7164 T1 - Estrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian women VL - 7 DO - 10.7717/peerj.7164 JO - PeerJ ER -en_US
dc.identifier.issn2167-8359
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/4934
dc.language.isoenen_US
dc.subjectT2DMen_US
dc.subjectESR1en_US
dc.subjectPvuII and XbaI polymorphismsen_US
dc.subjectNGSen_US
dc.subjectCVDen_US
dc.subjectPalestineen_US
dc.titleEstrogen receptor 1 gene polymorphisms (PvuII and XbaI) are associated with type 2 diabetes in Palestinian womenen_US
dc.typeArticleen_US
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