HPLC separation of phenolic phytochemicals from grape peels and seeds water extracts and their in-vitro antimalarial activities

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dc.contributor.authorAkkawi, Mutaz
dc.contributor.authorAbu-Lafi, Saleh
dc.contributor.authorAbu-Remeleh, Qassem
dc.contributor.authorKiswani, Marah
dc.contributor.authorQutob, Mutaz
dc.contributor.authorNusseibeh, Sameh
dc.contributor.authorLutgen, Pierre
dc.date.accessioned2019-01-27T18:38:02Z
dc.date.available2019-01-27T18:38:02Z
dc.date.issued2018-07-02
dc.description.abstractWater extracts of three grape types (black, shami and white) were separated using reversed phase HPLC-PDA and their in-vitro effect on β-hematin inhibition were investigated. The grape crude water extracts of peels and seeds impede the formation of β-hematin in vitro and therefore possess a significant antimalarial effect. Black grape peel extract gave superior activity as revealed by its absorption value in comparison to CQ positive control. In general, black and shami peels water extracts were slightly more active than their corresponding seeds extracts while surprisingly, the white grape peel extract was completely inactive. The same inactivity was noticed when black, shami and white grape juices as well as red and white wines were examined in-vitro. The lack in white grapes of the active phytochemicals that present at high levels in black and shami grapes explains the inactivity of the former. Several secondary plant phenolic metabolites may be responsible for the antimalarial activity and subsequently, one could infer that the antimalarial activity of water extract may be a result of the synergistic effect of its diverse phenolic phytochemicals.en_US
dc.description.sponsorshipNone.en_US
dc.identifier.citationAkkawi M, Abu-Lafi S, Abu-Remeleh Q, et al. HPLC separation of phenolic phytochemicals from grape peels and seeds water extracts and their invitro antimalarial activities. Pharm Pharmacol Int J. 2018;6(4):253‒259. DOI: 10.15406/ppij.2018.06.00183en_US
dc.identifier.issn2373-6367
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/4628
dc.language.isoenen_US
dc.publisherMedCraveen_US
dc.subjectHPLCen_US
dc.subjectgrapeen_US
dc.subjectseedsen_US
dc.subjectpeelsen_US
dc.subjectantimalariaen_US
dc.subjectβ-hematinen_US
dc.subjectchloroquineen_US
dc.subjecthemozoinen_US
dc.titleHPLC separation of phenolic phytochemicals from grape peels and seeds water extracts and their in-vitro antimalarial activitiesen_US
dc.typeArticleen_US
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