Current Status Regarding Tumour Progression, Surveillance, Diagnosis, Staging, and Treatment Of HCC: A Literature Review

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dc.contributor.authorMuntaser, S. Ahmad
dc.contributor.authorNursakinah, Suardi
dc.contributor.authorShukri, Ahmad
dc.contributor.authorHjouj, Mohammad
dc.contributor.authorOglat, Ammar A.
dc.contributor.authorAbunahel, Bassam M.
dc.contributor.authorMohamed, Aboubakr M.H
dc.contributor.authorMakhamrah, Osama
dc.date.accessioned2019-11-06T13:45:37Z
dc.date.available2019-11-06T13:45:37Z
dc.date.issued2019-04-21
dc.description.abstractHepatocellular carcinoma (HCC) is the most common primary malignant tumour of the liver, and is globally considered to be a major causes of cancer-associated mortality. The early diagnosis of HCC improves overall survival through the application of suitable treatment options. This article presents some of the techniques for the surveillance of HCC like ultrasonography and the use of tumour biomarkers such as α-fetoprotein (AFP), DesGamma-Carboxy Prothrombin (DCP) and others. Included in the discussion will be diagnostic methods like computed tomography (CT), magnetic resonance imaging (MRI), contrast enhancement ultrasound (CEUS), and fluorodeoxyglucose positron emission tomography hybrid with computed tomography (FDG PET/CT). Current molecular pathogenesis related to HCC and the molecular steps that determine the transition from benign to malignancy are also analysed. The HCC stages which depends on the Barcelona Clinic Liver Cancer (BCLC) algorithm are also discussed. Finally, this review article discusses the present therapeutic and treatment options for HCC such as resection, transplantation, or ablation used to treat early stage cancer. Also included will be trans-arterial chemoembolization (TACE) and Sorafenib for patients with intermediate and advanced-stage cancer, respectively.en_US
dc.identifier.issn2224-6509
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/4887
dc.language.isoenen_US
dc.publisherACT Publishing Group Ltd.en_US
dc.subjectHepatocellular carcinomaen_US
dc.subjectBarcelona Clinic Liver Canceren_US
dc.subjecttrans-arterial chemoembolizationen_US
dc.subjectSorafeniben_US
dc.titleCurrent Status Regarding Tumour Progression, Surveillance, Diagnosis, Staging, and Treatment Of HCC: A Literature Reviewen_US
dc.typeArticleen_US
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