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dc.contributor.authorHejaz, Hatem
dc.contributor.authorKaraman, Rafik
dc.contributor.authorKhamis, Mustafa
dc.date.accessioned2018-09-22T08:57:42Z
dc.date.available2018-09-22T08:57:42Z
dc.date.issued2011-04-15
dc.identifier.issn0948-5023
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/957
dc.description.abstractIt is believed that the bitter taste of paracetamol, a pain killer drug, is due to its hydroxyl group. Hence, it is expected that blocking the hydroxy group with a suitable linker could inhibit the interaction of paracetamol with its bitter taste receptor/s and hence masking its bitterness. Using DFT theoretical calculations we calculated proton transfers in ten different Kirby’s enzyme models, 1–10. The calculation results revealed that the reaction rate is linearly correlated with the distance between the two reactive centers (rGM) and the angle of the hydrogen bonding (α) formed along the reaction pathway. Based on these results three novel tasteless paracetamol prodrugs were designed and the thermodynamic and kinetic parameters for their proton transfers were calculated. Based on the experimental t1/2 (the time needed for the conversion of 50% of the reactants to products) and EM (effective molarity) values for processes 1–10 we have calculated the t1/2 values for the conversion of the three prodrugs to the parental drug, paracetamol. The calculated t1/2 values for ProD 1–3 were found to be 21.3 hours, 4.7 hours and 8 minutes, respectively. Thus, the rate by which the paracetamol prodrug undergoes cleavage to release paracetamol can be determined according to the nature of the linker of the prodrug (Kirby’s enzyme model 1–10). Further, blocking the phenolic hydroxyl group by a linker moiety is believed to hinder the paracetamol bitterness.en_US
dc.description.sponsorshipThe Karaman Co. is thanked for support of our computational facilities. Special thanks are also given to Angi Karaman, Donia Karaman, Rowan Karaman and Nardene Karaman for technical assistance.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.subjectDFT calculationsen_US
dc.subjectKirby’s enzyme modelsen_US
dc.subjectMasking bitter tasteen_US
dc.subjectParacetamol prodrugsen_US
dc.subjectProton transfer reactionen_US
dc.titleComputer-Assisted Design for Paracetamol Masking Bitter Taste Prodrugsen_US
dc.typeArticleen_US


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