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dc.contributor.authorElayyan, Sabrin
dc.contributor.authorKaraman, Donia
dc.contributor.authorMecca, Gennaro
dc.contributor.authorScrano, Laura
dc.contributor.authorBufo, Sabino A.
dc.contributor.authorKaraman, Rafik
dc.date.accessioned2018-09-16T08:40:23Z
dc.date.available2018-09-16T08:40:23Z
dc.date.issued2015-07-08
dc.identifier.issn2278 – 4357
dc.identifier.urihttps://dspace.alquds.edu/handle/20.500.12213/920
dc.description.abstractThe predrug (prodrug) term involves chemically modified inert compound which upon an administration releases the active parent drug to elicit its pharmacological response within the body. For many years, the predrug strategy has been extensively developed to solve many unwanted drug properties. This approach has several advantages over conventional drug administration and it has the potential to be quite effective method for the treatment of diseases in the future. In this mini-review we describe a number of antibacterial agents‘ predrugs, and the ways by which predrug strategy was exploited to overcome many pharmaceutical and pharmacokinetic problems that the parent active antibacterial drugs suffer from such as, low bioavailability by increasing or decreasing lipophilicity, site selectivity for higher absorption and less toxicity, short duration of action to increase patient compliance, rapid metabolism to increase oral bioavailability and masking bitter sensation which is crucial for geriatric and pediatric patient compliance.en_US
dc.language.isoen_USen_US
dc.publisherWJPPS,Dr. T Palen_US
dc.subjectPredrugsen_US
dc.subjectProdrugsen_US
dc.subjectAntibacterials predrugsen_US
dc.subjectAntibacterial agentsen_US
dc.subjectPredrug chemical approachen_US
dc.subjectIntramolecular processen_US
dc.subjectBitter sensationen_US
dc.titleAntibacterial Predrugs-from 1899 till 2015en_US
dc.typeArticleen_US


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