DNA compaction by poly (amido amine) dendrimers of ammonia cored and ethylene diamine cored
Date
2017-07-12
Authors
Qamhieh, K
Al-Shawwa, J
Journal Title
Journal ISSN
Volume Title
Publisher
IOP Publishing
Abstract
The complexes build–up of DNA and soft particles poly amidoamine (PAMAM)
dendrimers of ammonia cored of generations (G1-G6) and ethylenediamine cored of generations
(G1-G10) have been studied, using a new theoretical model developed by Qamhieh and coworkers.
The model describes the interaction between linear polyelectrolyte (LPE) chain and ion-penetrable
spheres. Many factors affecting LPE/dendrimer complex have been investigated such as dendrimer
generation, the Bjerrum length, salt concentration, and rigidity of the LPE chain represented by the
persistence length. It is found that the wrapping chain length around dendrimer increases by
increasing dendrimer`s generation, Bjerrum length, and salt concentration, while decreases by
increasing the persistence length of the LPE chain. Also we can conclude that the wrapping length
of LPE chain around ethylenediamine cored dendrimers is larger than its length around ammonia
cored dendrimers.