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Diclofenac Codrugs and Prodrugs-Three Decades of Design 

Dweib, khuloud; Jumaa, Salma; Thawabteh, Ameen; Scrano, Laura; Bufo, Sabino A.; Mecca, Gennaro; Karaman, Rafik (‎WJPPS,Dr. T Pal, 2015-06-08)
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release the active parent drug. The prodrug’s cleavage can be catalyzed by metabolic enzymes or can occur by chemical means without ...
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Computationally Designed Enzyme Models to Replace Natural Enzymes in Prodrug Approaches 

Karaman, Rafik (2012-11-16)
The striking efficiency of enzyme catalysis has inspired many organic chemists to explore enzyme mechanisms by studying certain intra molecular processes such as enzyme models which proceed faster than their intermolecular ...
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A Novel Mathematical Equation For Calculating The Number of ATP Molecules Generated From Sugars In Cells 

Karaman, Rafik; Khawaja, Yahya (WJPR,Tara Pal,WJPR, 2015-05-23)
Adenosine triphosphate (ATP) is critical for all life from the simplest to the most complex. All organisms from the microscopic to humans utilize ATP as the source for their primary energy currency. This manuscript ...
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Antibacterial Predrugs-from 1899 till 2015 

Elayyan, Sabrin; Karaman, Donia; Mecca, Gennaro; Scrano, Laura; Bufo, Sabino A.; Karaman, Rafik (WJPPS,Dr. T Pal, 2015-07-08)
The predrug (prodrug) term involves chemically modified inert compound which upon an administration releases the active parent drug to elicit its pharmacological response within the body. For many years, the predrug ...
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Mefenamic acid Prodrugs and Codrugs- Two Decades of Development 

Abu-Jaish, Alaa; Mecca, Gennaro; Jumaa, Salma; Thawabteh, Ameen; Karaman, Rafik (2015-06-05)
prodrugs are bioreversible derivatives of drug molecules that undergo intermolecular or intramolecular reactions by enzymatic or chemical biotransformation in the human body to give the corresponding active parent drugs ...
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Anti-cancer Prodrugs-Three Decades of Design 

Horani, Waad; Thawabteh, Ameen; Scrano, Laura; A. Bufo, Sabino; Mecca, Gennaro; Karaman, Rafik (2015-07-31)
The conventional old treatment method for cancer therapy is associated with severe side effects along with several limitations. Therefore, searching and developing new methods for cancer became crucial. This mini review ...
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Paracetamol biodegradation by activated sludge and photo-catalysis and its removal by a micelleclay complex, activated charcoal and reverse osmosis membranes 

Karaman, Rafik; Khamis, Mustafa; Abbadi, Jehad; Amro, Ahmad; Qurie, Mohannad; Ayyad, Ibrahim; Ayyash, Fatima; Hamarsheh, Omar; Yaqmour, Reem (Taylor & Francis, 2016-03-07)
Kinetic studies on the stability of the pain killer paracetamol in Al-Quds activated sludge demonstrated that paracetamol underwent biodegradation within less than one month to furnish p-aminophenol in high yields. ...
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Prodrugs targeting the central nervous system (cns) 

Salameh, Falasteen; Karaman, Donia; Karaman, Rafik (2015-08-07)
The classical approach for delivery of drugs into the central nervous system (CNS) is associated with adverse effects and it has many limitations. Therefore, extensive efforts have been done in searching and developing ...

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Karaman, Rafik (8)
Mecca, Gennaro (4)Scrano, Laura (3)Thawabteh, Ameen (3)Bufo, Sabino A. (2)Jumaa, Salma (2)Karaman, Donia (2)A. Bufo, Sabino (1)Abbadi, Jehad (1)Abu-Jaish, Alaa (1)... View MoreSubjectProdrugs (3)Enzyme models (2)Intramolecular process (2)Predrugs (2)Targeted prodrugs (2)activated charcoal (1)Adenosine triphosphate (1)ADEPT (1)advanced oxidation techniques (1)Al-Quds Sludge (1)... View MoreDate Issued2015 (6)2012 (1)2016 (1)Has File(s)Yes (8)

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