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Diclofenac Codrugs and Prodrugs-Three Decades of Design
(WJPPS,Dr. T Pal, 2015-06-08)
Prodrugs or predrugs are inactive molecules which become active after in vivo conversion to release the active parent drug. The prodrug’s cleavage can be catalyzed by metabolic enzymes or can occur by chemical means without ...
Computationally Designed Enzyme Models to Replace Natural Enzymes in Prodrug Approaches
(2012-11-16)
The striking efficiency of enzyme catalysis has inspired many
organic chemists to explore enzyme mechanisms by studying certain
intra molecular processes such as enzyme models which proceed faster
than their intermolecular ...
A Novel Mathematical Equation For Calculating The Number of ATP Molecules Generated From Sugars In Cells
(WJPR,Tara Pal,WJPR, 2015-05-23)
Adenosine triphosphate (ATP) is critical for all life from the simplest
to the most complex. All organisms from the microscopic to humans
utilize ATP as the source for their primary energy currency. This
manuscript ...
Antibacterial Predrugs-from 1899 till 2015
(WJPPS,Dr. T Pal, 2015-07-08)
The predrug (prodrug) term involves chemically modified inert
compound which upon an administration releases the active parent
drug to elicit its pharmacological response within the body. For many
years, the predrug ...
Mefenamic acid Prodrugs and Codrugs- Two Decades of Development
(2015-06-05)
prodrugs are bioreversible derivatives of drug molecules that undergo
intermolecular or intramolecular reactions by enzymatic or chemical
biotransformation in the human body to give the corresponding active
parent drugs ...
Anti-cancer Prodrugs-Three Decades of Design
(2015-07-31)
The conventional old treatment method for cancer therapy is associated with severe side effects along with several limitations. Therefore, searching and developing new methods for cancer became crucial. This mini review ...
Paracetamol biodegradation by activated sludge and photo-catalysis and its removal by a micelleclay complex, activated charcoal and reverse osmosis membranes
(Taylor & Francis, 2016-03-07)
Kinetic studies on the stability of the pain killer paracetamol in Al-Quds activated sludge demonstrated that paracetamol underwent biodegradation within less than one month to furnish p-aminophenol in high yields. ...
Prodrugs targeting the central nervous system (cns)
(2015-08-07)
The classical approach for delivery of drugs into the central nervous
system (CNS) is associated with adverse effects and it has many
limitations. Therefore, extensive efforts have been done in searching
and developing ...